abstract：:Technical progress in the field of next-generation sequencing, mass spectrometry and bioinformatics facilitates the study of highly complex biological samples such as taxonomic and functional characterization of microbial communities that virtually colonize all present ecological niches. Compared to the structural inf...

journal_title：Computational and structural biotechnology journal

authors： Deusch S,Tilocca B,Camarinha-Silva A,Seifert J

更新日期：2014-12-24 00:00:00

abstract：:RNA-Seq was used to examine the microbial, eukaryotic, and viral communities in water catchments ('tanks') formed by tropical bromeliads from Costa Rica. In total, transcripts with taxonomic affiliation to a wide array of bacteria, archaea, and eukaryotes, were observed, as well as RNA-viruses that appeared related to...

journal_title：Computational and structural biotechnology journal

authors： Goffredi SK,Jang GE,Haroon MF

更新日期：2014-12-13 00:00:00

abstract：:Inflammation shifts the hemostatic mechanisms in favor of thrombosis. Upon tissue damage or infection, a sudden increase of extracellular ATP occurs, that might contribute to the crosstalk between inflammation and thrombosis. On platelets, P2X1 receptors act to amplify platelet activation and aggregation induced by ot...

journal_title：Computational and structural biotechnology journal

authors： Oury C,Lecut C,Hego A,Wéra O,Delierneux C

更新日期：2014-11-28 00:00:00

abstract：:The challenging task of studying and modeling complex dynamics of biological systems in order to describe various human diseases has gathered great interest in recent years. Major biological processes are mediated through protein interactions, hence there is a need to understand the chaotic network that forms these pr...

journal_title：Computational and structural biotechnology journal

authors： Sevimoglu T,Arga KY

更新日期：2014-09-03 00:00:00

abstract：:Hydroxynitrile lyases (HNLs) are powerful carbon-carbon bond forming enzymes. The reverse of their natural reaction - the stereoselective addition of hydrogen cyanide (HCN) to carbonyls - yields chiral cyanohydrins, versatile building blocks for the pharmaceutical and chemical industry. Recently, bacterial HNLs have b...

journal_title：Computational and structural biotechnology journal

authors： Wiedner R,Gruber-Khadjawi M,Schwab H,Steiner K

更新日期：2014-07-08 00:00:00

abstract：:Compounds that inhibit the catalytic function of lysine-specific demethylase 1 (LSD1) are interesting as therapeutic agents. Recently, we identified three lysine-phenylcyclopropylamine conjugates, NCD18, NCD25, and NCD41, which are potent LSD1 inactivators. However, in our previous study, because we tested those compo...

journal_title：Computational and structural biotechnology journal

authors： Itoh Y,Ogasawara D,Ota Y,Mizukami T,Suzuki T

更新日期：2014-02-15 00:00:00

abstract：:ChIP-seq experiments identify genome-wide profiles of DNA-binding molecules including transcription factors, enzymes and epigenetic marks. Biological replicates are critical for reliable site discovery and are required for the deposition of data in the ENCODE and modENCODE projects. While early reports suggested two r...

journal_title：Computational and structural biotechnology journal

authors： Yang Y,Fear J,Hu J,Haecker I,Zhou L,Renne R,Bloom D,McIntyre LM

更新日期：2014-01-31 00:00:00

abstract：:We report a study of the interaction between internalin A (inlA) and human or murine E-cadherin (Ecad). inlA is used by Listeria monocytogenes to internalize itself into host cell, but the bacterium is unable to invade murine cells, which has been attributed to the difference in sequence between hEcad and mEcad. Using...

journal_title：Computational and structural biotechnology journal

authors： Genheden S,Eriksson LA

更新日期：2013-12-15 00:00:00

abstract：:Murine models with modified gene function as a result of N-ethyl-N-nitrosourea (ENU) mutagenesis have been used to study phenotypes resulting from genetic change. This study investigated genetic factors associated with red blood cell (RBC) physiology and structural integrity that may impact on blood component storage ...

journal_title：Computational and structural biotechnology journal

authors： Kildey K,Flower RL,Tran TV,Tunningley R,Harris J,Dean MM

更新日期：2013-09-23 00:00:00

abstract：:The development of new high-throughput sequencing technologies has increased dramatically the number of successful genomic projects. Thus, draft genomic sequences of more than 60 plant species are currently available. Suitable bioinformatics tools are being developed to assemble, annotate and analyze the enormous numb...

journal_title：Computational and structural biotechnology journal

authors： Martinez M

更新日期：2013-08-14 00:00:00

abstract：:Biomimetic design of new materials uses nature as antetype, learning from billions of years of evolution. This work emphasizes the mechanical and tribological properties of skin, combining both hardness and wear resistance of its surface (the stratum corneum) with high elasticity of the bulk (epidermis, dermis, hypode...

journal_title：Computational and structural biotechnology journal

authors： Lackner JM,Waldhauser W,Major L,Teichert C,Hartmann P

更新日期：2013-05-08 00:00:00

abstract：:Metabolomics is a relatively new high-throughput technology that aims at measuring all endogenous metabolites within a biological sample in an unbiased fashion. The resulting metabolic profiles may be regarded as functional signatures of the physiological state, and have been shown to comprise effects of genetic regul...

journal_title：Computational and structural biotechnology journal

authors： Bartel J,Krumsiek J,Theis FJ

更新日期：2013-03-22 00:00:00

abstract：:Basic chemometric methods for making empirical regression models for QSPR/QSAR are briefly described from a user's point of view. Emphasis is given to PLS regression, simple variable selection and a careful and cautious evaluation of the performance of PLS models by repeated double cross validation (rdCV). A demonstra...

journal_title：Computational and structural biotechnology journal

authors： Varmuza K,Filzmoser P,Dehmer M

更新日期：2013-03-02 00:00:00

abstract：:Polyketides are an important group of secondary metabolites, many of which have important industrial applications in the food and pharmaceutical industries. Polyketides are synthesized from one of three classes of enzymes differentiated by their biochemical features and product structure: type I, type II or type III p...

journal_title：Computational and structural biotechnology journal

authors： Lussier FX,Colatriano D,Wiltshire Z,Page JE,Martin VJ

更新日期：2013-02-22 00:00:00

abstract：:Recent years have witnessed a spurt of activities in the elucidation of the molecular function of a class of proteins with great potential in biomass degradation. GH61 proteins are of fungal origin and were originally classified in family 61 of the glycoside hydrolases. From the beginning they were strongly suspected ...

journal_title：Computational and structural biotechnology journal

authors： Lo Leggio L,Welner D,De Maria L

更新日期：2012-11-30 00:00:00

abstract：:Motility studies of cells often rely on computer software that analyzes time-lapse recorded movies and establishes cell trajectories fully automatically. This raises the question of reproducibility of results, since different programs could yield significantly different results of such automated analysis. The fact tha...

journal_title：Computational and structural biotechnology journal

authors： Grădinaru C,Lopacińska JM,Huth J,Kestler HA,Flyvbjerg H,Mølhave K

更新日期：2012-11-21 00:00:00

abstract：:Numerous bioactive natural products are synthesised by modular polyketide synthases. These compounds can be made in high yield by native multienzyme assembly lines. However, formation of analogues by genetically engineered systems is often considerably less efficient. Biochemical studies on intact polyketide synthase ...

journal_title：Computational and structural biotechnology journal

authors： Caffrey P

更新日期：2012-11-17 00:00:00

abstract：:This mini review addresses recent developments in computational enzyme design. Successful protocols as well as known issues and limitations are discussed from an energetic perspective. It will be argued that improved results can be obtained by including a dynamic treatment in the design protocol. Finally, a molecular ...

journal_title：Computational and structural biotechnology journal

authors： Linder M

更新日期：2012-10-23 00:00:00